Epitope mapping of SARS-CoV-2 spike protein differentiates the antibody binding activity in vaccinated and infected individuals

نویسندگان

چکیده

Previous studies have attempted to characterize the antibody response of individuals SARS-CoV-2 virus on a linear peptide level by utilizing microarrays. These helped identify epitopes that potential be used for diagnostic tests infected individuals. The immunological responses who received two most popular vaccines available in US, Moderna mRNA-1273 or Pfizer BNT162b2 mRNA vaccines, not been characterized. We aimed peptides spike protein elicited high IgG IgA binding activity and compare immunoreactivity those both doses either vaccine Our results revealed significant among recently Some these are located near variable regions receptor domains as well conserved region c-terminal implicated infectivity SARS-CoV-2. Vaccinated lacked distinct markers despite overall being similar.

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ژورنال

عنوان ژورنال: Frontiers in virology

سال: 2023

ISSN: ['2673-818X']

DOI: https://doi.org/10.3389/fviro.2023.988109